![]() ![]() Recent publications have reported that ZSS has many attractive pharmacological activities, including protection of the cardiovascular system, anti-hyperlipidemia, and anxiolytic effects, , ]. ZSS was first listed in the classical book Ming Yi Bie Lu in Han Dynasty of the Chinese history for the treatment of insomnia. Chou, has been widely used in many patented medicines and functional foods in China and other Asian countries, such as Korea and Japan. The comparative pharmacokinetics-based UHPLC-Q-Orbitrap-MS using full-scan mode can therefore provide a reliable and suitable means for the screening of potentially effective substances applied as quality markers of ZSS.įor 2000 years, Ziziphi Spinosae Semen (ZSS), the semen of Ziziphus jujuba Mill. ![]() These results indicate that the pathological state of insomnia altered the plasma pharmacokinetics of spinosin, 6 ‴-feruloylspinosin, JuA, and JuB in the ZSS aqueous extract, providing an experimental basis for the role of ZSS in insomnia treatment. The pharmacokinetic parameters of coclaurine and magnoflorine were not evidently affected between the two groups. The T 1/2 of JuA in the IM group was significantly accelerated. The T max values of JuA and JuB in IM rats were significantly lower than those in NC rats. The systemic exposures of spinosin and 6 ‴-feruloylspinosin were decreased in the IM group compared to the NC group, while plasma clearance (CL) was significantly increased. ![]() The established approach was successfully applied to a comparative pharmacokinetic study. An ultra-high-performance liquid chromatography coupled with quadrupole orbitrap mass (UHPLC-Q-Orbitrap-MS) method was developed and validated for the simultaneous determination of coclaurine, magnoflorine, spinosin, 6 ‴-feruloylspinosin, jujuboside A (JuA), and jujuboside B (JuB) in ZSS in rat plasma. Herein, we described for the first time a comparative pharmacokinetics study of the six major compounds of ZSS in normal control (NC) and para-chlorophenylalanine (PCPA)-induced insomnia model (IM) rats that were orally administered the aqueous extract of ZSS. Ziziphi Spinosae Semen (ZSS), a traditional Chinese medicine, is used in clinics for the treatment of insomnia in China and other Asian countries. ![]()
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